2021 Strength Of Schedule
Based on opponents' winning percentage in 2020
| Rank | Team | Opp. Record | Opp. Win Pct. |
| 1 | Pittsburgh Steelers | 143-111-2 | 0.563 |
| 2 | Baltimore Ravens | 142-112-2 | 0.559 |
| 3 | Chicago Bears | 141-114-1 | 0.553 |
| 4 | Detroit Lions | 138-116-2 | 0.543 |
| 5 | Cincinnati Bengals | 138-118-0 | 0.539 |
| 6 | Minnesota Vikings | 137-118-1 | 0.537 |
| 7 | Las Vegas Raiders | 134-120-2 | 0.527 |
| 8 | Green Bay Packers | 133-122-1 | 0.521 |
| 9 | Cleveland Browns | 132-122-2 | 0.52 |
| 10 | Houston Texans | 132-124-0 | 0.516 |
| 11 | Jacksonville Jaguars | 129-126-1 | 0.506 |
| 12 | Los Angeles Rams | 129-127-0 | 0.504 |
| 13 | San Francisco 49ers | 128-127-1 | 0.502 |
| 13 | New York Jets | 128-127-1 | 0.502 |
| 15 | Los Angeles Chargers | 126-128-2 | 0.496 |
| 15 | Arizona Cardinals | 127-129-0 | 0.496 |
| 15 | Seattle Seahawks | 127-129-0 | 0.496 |
| 15 | New England Patriots | 127-129-0 | 0.496 |
| 19 | Tennessee Titans | 126-130-0 | 0.492 |
| 19 | Kansas City Chiefs | 125-129-2 | 0.492 |
| 21 | Carolina Panthers | 124-131-1 | 0.486 |
| 22 | Washington Football Team | 123-131-2 | 0.484 |
| 23 | Buffalo Bills | 123-133-0 | 0.48 |
| 23 | Denver Broncos | 122-132-2 | 0.48 |
| 25 | Atlanta Falcons | 122-133-1 | 0.479 |
| 26 | Miami Dolphins | 122-134-0 | 0.477 |
| 27 | New Orleans Saints | 120-135-1 | 0.471 |
| 28 | New York Giants | 118-136-2 | 0.465 |
| 28 | Indianapolis Colts | 119-137-0 | 0.465 |
| 30 | Dallas Cowboys | 115-139-2 | 0.453 |
| 31 | Tampa Bay Buccaneers | 115-140-1 | 0.451 |
| 32 | Philadelphia Eagles | 115-141-0 | 0.449 |