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Buffalo NFL Draft Choices
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| Year | Round | Overall | Name | Team | Position | School |
| 2021 | 3 | 79 | Malcolm Koonce | Raiders | DE | Buffalo |
| 2017 | 7 | 251 | Mason Schreck | Bengals | TE | Buffalo |
| 2015 | 6 | 214 | Kristjan Sokoli | Seahawks | DT | Buffalo |
| 2014 | 1 | 5 | Khalil Mack | Raiders | LB | Buffalo |
| 2013 | 5 | 147 | Steven Means | Buccaneers | LB | Buffalo |
| 2011 | 5 | 143 | Josh Thomas | Cowboys | CB | Buffalo |
| 2010 | 6 | 193 | James Starks | Packers | RB | Buffalo |
| 2008 | 6 | 169 | Trevor Scott | Raiders | DE | Buffalo |
| 2008 | 7 | 236 | Jamey Richard | Colts | OC | Buffalo |
| 2000 | 7 | 233 | Drew Haddad | Bills | WR | Buffalo |
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